A group of yuppie New York City friends meet together to bid their friend, Rob, who is about to leave the country for a new job. The party includes: Rob's brother, Jason, longtime crush Beth, and Hud, Rob's silly friend who documents the night, and Marlena, another friend on whom Hud develops a crush. In the middle of the party, after Beth stormed out in a fight, a monster attacks New York City. While trying to leave the city with the millions of New Yorkers forced to evacuate, the friends' journey is ruined by the monster's destruction of the Brooklyn Bridge. On their way to find another route out of the city, the friends get sidetracked and are compelled to find the injured Beth. All the while, the monster continues massacring America's largest city... Statue of Liberty included.